Publications
Research publications
- 2026
Correlations between causal effect sizes of proximal SNPs vary with functional annotations and implicate stabilizing selection
Martin Jinye Zhang, Arun Durvasula, Colby Chiang, Evan M. Koch, …, Shamil Sunyaev, Alkes L. Price
- 2026
Inference of elevated mutation rates and variant effects using 700k exomes
Prathitha Kar, Mikhail A. Moldovan, Jeremy Guez, …, Evan M. Koch, Vladimir B. Seplyarskiy, Shamil Sunyaev
- 2026
Integrating 730,947 exome sequences with clinical literature improves gene discovery
Jeremy Guez, Julia K. Goodrich, Mikhail A. Moldovan, …, Evan M. Koch, …, Kaitlin E. Samocha, Konrad J. Karczewski
- 2025
Hotspots of human mutation point to clonal expansions in spermatogonia
Vladimir B. Seplyarskiy, Mikhail A. Moldovan, Evan M. Koch, Prathitha Kar, Matthew D. C. Neville, Raheleh Rahbari, Shamil Sunyaev
- 2024
Genetic association data are broadly consistent with stabilizing selection shaping human common diseases and traits
Evan M. Koch, Noah J Connally, Nikolas Baya, …, Alex Bloemendal, Shamil Sunyaev
- 2023
A mutation rate model at the basepair resolution identifies the mutagenic effect of polymerase III transcription
Vladimir B. Seplyarskiy, Evan M. Koch, Daniel J. Lee, Joshua S. Lichtman, Harding H. Luan, Shamil Sunyaev
- 2023
Mutation rates and adaptive variation among the clinically dominant clusters of Mycobacterium abscessus
Nicoletta Commins, Mark R. Sullivan, Kerry McGowen, Evan M. Koch, Eric J. Rubin, Maha Farhat
- 2023
Recurrent mutation in the ancestry of a rare variant
John Wakeley, Wai-Tong Louis Fan, Evan M. Koch, Shamil Sunyaev
Reviews & perspectives
- 2024
Deciphering the impact of genomic variation on function
Writing group (ordered by contribution), J Engreitz, Heather A. Lawson, …, Evan M. Koch, …, Jay Shendure, Vikram Agarwal
- 2023
A biology-aware mutation rate model for human germline
Evan M. Koch, Vladimir Seplyarskiy, Shamil R Sunyaev
- 2021
Maintenance of complex trait variation: classic theory and modern data
Evan M. Koch, Shamil Sunyaev